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Clobenzorex is a prodrug of D-Amphetamine. The 2-chlorobenzyl group is primarily cleaved through N-dealkylation via CYP3A4 into D-Amph. It's molecular weight is about double that of Amph, so the theoretical mass of Amph metabolites could be up to 50% of Clobenzorex's mass. So I think a CYP3A4 inducer would increase the efficiency and rate of ...

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Clobenzorex can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC …

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